Ma Somsouk, MD, MAS

Professor

Center for Vulnerable Populations, Gastroenterology

1. Leverage electronic health data to implement novel population health services and care coordination for complex populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

2. Develop intestinal organoids from primary human samples to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

Education
2022 - Diversity, Equity, and Inclusion Champion Training, University of California
M.A.S., 2008 - , UCSF, Epidemiology and Biostatistics
Fellowship, 2008 - , UCSF, Gastroenterology & Hepatology
Residency, 2005 - , UCLA-Harbor Medical Center
M.D., 2002 - , Harvard Medical School
Fellowship, 2001 - , Beijing Medical University, Research Scholar
B.A., 1997 - , Pomona College, Chemistry
Honors and Awards
  • Dean M. Craig Endowed Chair in Gastrointestinal Medicine, UCSF, 2016
  • AGA Fellow, American Gastroenterology Association, 2015
  • Distinction in Mentoring, UCSF Academic Senate Nomination, 2015
  • Paul Dudley White / Andrew Sellard Fellowship, Harvard, 2001
  • Magna Cum Laude, Pomona College, 1997
Websites
Publications

  1. Peluso MJ, Ryder D, Flavell RR, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez AE, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Vasquez JJ, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambhir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ. Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection. Science translational medicine 2024. PMID: 38959327


  2. Colquhoun DA, Somsouk M, Chen CL. Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data. Anesthesiology 2024. PMID: 38629962


  3. McClellan SP, Khan T, Rafferty H, Wong J, La S, Patel S, Somsouk M. The effect of mailed outreach on FIT completion among patients aged 45-50 in a safety net healthcare system. Cancer causes & control : CCC 2024. PMID: 38822978


  4. Burns S, Griffith M, Patel S, Sarkar U, Somsouk M. Electronic coding for abnormal fecal immunochemical test is associated with increased colonoscopy completion. The American journal of gastroenterology 2024. PMID: 38488169


  5. Odufalu FD, Sewell JL, Rudrapatna V, Somsouk M, Mahadevan U. Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center. Inflammatory bowel diseases 2023. PMID: 36943305


  6. Viramontes O, Martinez D, Somsouk M. Intestinal Metaplasia Associated with Symptoms of Dyspepsia. Research square 2023. PMID: 37886477


  7. Patel S, Sewell JL, Bhuket T, Somsouk M. Delivering High-Quality, Efficient Gastroenterology Care to Vulnerable and Underserved Populations: Special Considerations and Possible Solutions. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. PMID: 37634855


  8. Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ. Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19. medRxiv : the preprint server for health sciences 2023. PMID: 37577714


  9. Santiago-Rodríguez EJ, Hoeft KS, Lugtu K, McGowen M, Ofman D, Adler J, Somsouk M, Potter MB. Implementation of a novel program to support colorectal cancer screening in a community health center consortium before and after the onset of COVID-19: a qualitative study of stakeholders' perspectives. Implementation science communications 2023. PMID: 37218022


  10. Duarte MJ, Tien PC, Somsouk M, Price JC. The human microbiome and gut-liver axis in people living with HIV. Current HIV/AIDS reports 2023. PMID: 37129834


  11. Burns S, Wang J, Somsouk M. Effect of Mailed Fecal Immunochemical Test Outreach for Patients Newly Eligible for Colorectal Cancer Screening. Digestive diseases and sciences 2023. PMID: 36964863


  13. Burns S, Somsouk M. Durability of FIT Screening After Cessation of a Screening Outreach Intervention. Digestive diseases and sciences 2022. PMID: 36357595


  14. Altinbas A, Holmes JA, Salloum S, Lidofsky A, Alatrakchi N, Somsouk M, Hunt P, Deeks S, Chew KW, Lauer G, Kruger A, Lin W, Chung RT. LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients. Biomarkers in medicine 2022. PMID: 35786977


  15. Khoong EC, Rivadeneira NA, Pacca L, Schillinger D, Lown D, Babaria P, Gupta N, Pramanik R, Tran H, Whitezell T, Somsouk M, Sarkar U. Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review. Journal of general internal medicine 2022. PMID: 35641722


  16. Mukherjea A, Shariff-Marco S, Yang J, Tseng W, Palaniappan L, Li J, Ivey SL, Somsouk M, Gomez SL. Determinants of Colorectal Cancer Screening among South Asian Americans. Journal of Asian health 2022. PMID: 35909807


  17. Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A. From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center. TO REMOVE 2022. PMID: 35342686


  18. Chang HW, Yan D, Singh R, Bui A, Lee K, Truong A, Milush JM, Somsouk M, Liao W. Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host‒Microbe Associations. JID innovations : skin science from molecules to population health 2022. PMID: 35757783


  19. Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U. A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems. Journal of patient safety 2022. PMID: 32467445


  20. Sangaramoorthy M, Yang J, Guan A, DeRouen MC, Tana MM, Somsouk M, Thompson CA, Gibbons J, Ho C, Chu JN, Cheng I, Gomez SL, Shariff-Marco S. Asian American/Pacific Islander and Hispanic Ethnic Enclaves, Neighborhood Socioeconomic Status, and Hepatocellular Carcinoma Incidence in California: An Update. TO REMOVE 2021. PMID: 34853019


  21. Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. Gag p24 is a Marker of HIV Expression in Tissues and Correlates with Immune Response. The Journal of infectious diseases 2021. PMID: 33693750


  22. Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T. Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease. Cell reports. Medicine 2021. PMID: 34467254


  23. Lee B, Keyes E, Rachocki C, Grimes B, Chen E, Vittinghoff E, Ladabaum U, Somsouk M. Increased Colorectal Cancer Screening Sustained with Mailed Fecal Immunochemical Test Outreach. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021. PMID: 34280552


  24. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Scandinavian journal of gastroenterology 2021. PMID: 33941035


  25. Ge J, Najafi N, Zhao W, Somsouk M, Fang M, Lai JC. A Methodology to Generate Longitudinally Updated Acute-On-Chronic Liver Failure Prognostication Scores From Electronic Health Record Data. Hepatology communications 2021. PMID: 34141990


  26. Wang A, Lee B, Patel S, Whitaker E, Issaka RB, Somsouk M. Selection of patients for large mailed fecal immunochemical test colorectal cancer screening outreach programs: A systematic review. Journal of medical screening 2021. PMID: 33683155


  27. Patel S, Issaka RB, Chen E, Somsouk M. Colorectal Cancer Screening and COVID-19. The American journal of gastroenterology 2021. PMID: 33038127


  28. Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. Journal of virology 2020. PMID: 33115867


  29. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. AIDS (London, England) 2020. PMID: 32910065


  30. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. eLife 2020. PMID: 32990219


  31. Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature 2020. PMID: 32848246


  32. Lee B, Patel S, Rachocki C, Issaka R, Vittinghoff E, Shapiro JA, Ladabaum U, Somsouk M. Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial. Journal of general internal medicine 2020. PMID: 32748345


  33. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS (London, England) 2020. PMID: 32675558


  34. Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M. Obesity and metabolic outcomes in a safety-net health system. Biodemography and social biology 2020. PMID: 32727275


  35. Issaka RB, Somsouk M. Colorectal Cancer Screening and Prevention in the COVID-19 Era. JAMA health forum 2020. PMID: 34532717


  36. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. Journal of acquired immune deficiency syndromes (1999) 2020. PMID: 32168200


  37. Issaka RB, Rachocki C, Huynh MP, Chen E, Somsouk M. Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System. Digestive diseases and sciences 2020. PMID: 32236885


  38. Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U. Effectiveness and Cost of Organized Outreach for Colorectal Cancer Screening: A Randomized, Controlled Trial. Journal of the National Cancer Institute 2020. PMID: 31187126


  39. Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR. Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy. The Journal of infectious diseases 2019. PMID: 31796951


  40. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nature immunology 2020. PMID: 32066947


  41. Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S. The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites. Journal of virology 2019. PMID: 31723024


  42. Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S. Disparities in Hepatocellular Carcinoma Incidence in California: An Update. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019. PMID: 31719066


  43. Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR. TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nature communications 2019. PMID: 31562318


  44. Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N. Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. Digestive diseases and sciences 2019. PMID: 31302808


  45. Vujkovic-Cvijin I, Somsouk M. HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration. Current HIV/AIDS reports 2019. PMID: 31037552


  46. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ. CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals. Pathogens & immunity 2019. PMID: 31139759


  47. Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM. Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART. Pathogens & immunity 2019. PMID: 31139758


  48. Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N. Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. United European gastroenterology journal 2019. PMID: 31316785


  49. Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection. PLoS pathogens 2019. PMID: 30973942


  50. Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA. Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice. Viruses 2019. PMID: 30871222


  51. Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M. Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018. PMID: 30503967


  52. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS pathogens 2018. PMID: 30440043


  53. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Preventive medicine 2018. PMID: 30367972


  54. Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. Macrophage Activation Marker Soluble CD163 is a Dynamic Marker of Liver Fibrogenesis in HIV/HCV Coinfection. The Journal of infectious diseases 2018. PMID: 29868909


  55. Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S. Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018. PMID: 30115679


  56. Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM. Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. Autoimmunity 2018. PMID: 29890851


  57. Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M. Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018. PMID: 29660528


  58. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS pathogens 2018. PMID: 29505600


  59. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS pathogens 2018. PMID: 29470552


  60. Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM. Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. Volume 113 of Issue 2. The American journal of gastroenterology 2018. PMID: 29380822


  61. Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection. Journal of immunology (Baltimore, Md. : 1950) 2018. PMID: 29352005


  62. Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M. Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018. PMID: 29330098


  63. Ivey SL, Mukherjea A, Patel A, Kapoor N, Rau S, Kazi E, Bhatia J, Somsouk M, Tseng W. Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators. Journal of health care for the poor and underserved 2018. PMID: 30449755


  64. Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A. The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer. Volume 37 of Issue 1. Health affairs (Project Hope) 2018. PMID: 29309234


  65. Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV, Kaltenbach T. Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications. Volume 87 of Issue 4. Gastrointestinal endoscopy 2017. PMID: 29208464


  66. Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL. Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Volume 11 of Issue 3. Mucosal immunology 2017. PMID: 29139476


  67. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. Volume 33 of Issue S1. AIDS research and human retroviruses 2017. PMID: 28882052


  68. Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM. Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea. Volume 18 of Issue 5-6. HIV clinical trials 2017. PMID: 29210625


  69. Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Volume 2 of Issue 3. Pathogens & immunity 2017. PMID: 28936485


  70. Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE. Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection. Volume 2 of Issue 2. Pathogens & immunity 2017. PMID: 28782046


  71. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Volume 8 of Issue 5. Gut microbes 2017. PMID: 28541799


  72. Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR. Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy. Volume 215 of Issue 6. The Journal of infectious diseases 2017. PMID: 28453847


  73. Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. Volume 13 of Issue 2. PLoS pathogens 2017. PMID: 28241080


  74. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. Volume 13 of Issue 2. PLoS pathogens 2017. PMID: 28207890


  75. Kouanda AM, Somsouk M, Sewell JL, Day LW. Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis. Volume 86 of Issue 1. Gastrointestinal endoscopy 2017. PMID: 28174123


  76. Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M. Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System. Volume 112 of Issue 2. The American journal of gastroenterology 2016. PMID: 28154400


  77. Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Volume 10 of Issue 4. Mucosal immunology 2016. PMID: 27827375


  78. Paquin-Proulx D, Ching C, Vujkovic-Cvijin I, Fadrosh D, Loh L, Huang Y, Somsouk M, Lynch SV, Hunt PW, Nixon DF, SenGupta D. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. Volume 10 of Issue 1. Mucosal immunology 2016. PMID: 27049061


  79. Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M. Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer. Volume 82 of Issue 3. Gastrointestinal endoscopy 2015. PMID: 25936449


  80. von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. Volume 212 of Issue 4. The Journal of infectious diseases 2015. PMID: 25712966


  81. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. Gut epithelial barrier and systemic inflammation during chronic HIV infection. Volume 29 of Issue 1. AIDS (London, England) 2015. PMID: 25387317


  82. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial. Volume 9 of Issue 12. PloS one 2014. PMID: 25545673


  83. Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW. Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions. Volume 211 of Issue 7. The Journal of infectious diseases 2014. PMID: 25344521


  84. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon DF, SenGupta D. The CD8? memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection. Volume 88 of Issue 23. Journal of virology 2014. PMID: 25253339


  85. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. Volume 10 of Issue 5. PLoS pathogens 2014. PMID: 24831517


  86. Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R. Esophageal varices on computed tomography and subsequent variceal hemorrhage. Volume 39 of Issue 2. Abdominal imaging 2014. PMID: 24366107


  87. Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME. Challenges and possible solutions to colorectal cancer screening for the underserved. Volume 106 of Issue 4. Journal of the National Cancer Institute 2014. PMID: 24681602


  88. Day LW, Siao D, Inadomi JM, Somsouk M. Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis. Volume 46 of Issue 5. Endoscopy 2014. PMID: 24627086


  89. Day LW, Lin L, Somsouk M. Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis. Volume 2 of Issue 1. Endoscopy international open 2014. PMID: 26134610


  90. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance between peripheral and colonic markers of inflammation during suppressive ART. Volume 65 of Issue 2. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 24121758


  91. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. Volume 28 of Issue 3. AIDS (London, England) 2014. PMID: 24322272


  92. Sewell JL, Somsouk M, Shah SC, Day LW. Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply. Volume 38 of Issue 11-12. Alimentary pharmacology & therapeutics 2013. PMID: 24206377


  93. Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Volume 110 of Issue 51. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 24277811


  94. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. Volume 9 of Issue 10. PLoS pathogens 2013. PMID: 24130489


  95. Siao D, Somsouk M. Helicobacter pylori: evidence-based review with a focus on immigrant populations. Volume 29 of Issue 3. Journal of general internal medicine 2013. PMID: 24065381


  96. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. Volume 27 of Issue 14. AIDS (London, England) 2013. PMID: 24157906


  97. Shah SC, Day LW, Somsouk M, Sewell JL. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Volume 38 of Issue 8. Alimentary pharmacology & therapeutics 2013. PMID: 24004101


  98. Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Volume 5 of Issue 193. Science translational medicine 2013. PMID: 23843452


  99. Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG. The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial. Volume 121 of Issue 23. Blood 2013. PMID: 23589670


  100. Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M. Late presentation of colorectal cancer in a vulnerable population. Volume 108 of Issue 4. The American journal of gastroenterology 2013. PMID: 23552303


  101. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. Volume 9 of Issue 2. PLoS pathogens 2013. PMID: 23459007


  102. Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Volume 121 of Issue 7. Blood 2012. PMID: 23243281


  103. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. Volume 29 of Issue 1. AIDS research and human retroviruses 2012. PMID: 22998457


  104. Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C, Somsouk M, El-Nachef N, Hayward RA. Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Volume 172 of Issue 7. Archives of internal medicine 2012. PMID: 22493463


  105. Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Volume 74 of Issue 4. Gastrointestinal endoscopy 2011. PMID: 21951478


  106. Day LW, Cello JP, Somsouk M, Inadomi JM. Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test. Volume 30 of Issue 5. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2011. PMID: 21948130


  107. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. Volume 85 of Issue 21. Journal of virology 2011. PMID: 21880771


  108. Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW. Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk. Volume 17 of Issue 2. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2011. PMID: 21280185


  109. Somsouk M, Guy J, Biggins SW, Vittinghoff E, Kohn MA, Inadomi JM. Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease. Volume 30 of Issue 7. Alimentary pharmacology & therapeutics 2009. PMID: 19604177


  110. Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW. New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt. Volume 7 of Issue 11. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009. PMID: 19560557


  111. Somsouk M, Yee HF, Biggins SW. Understanding liver health using the National Center for Health Statistics. Volume 54 of Issue 11. Digestive diseases and sciences 2009. PMID: 19424799


  112. Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ. A cost-utility analysis of ablative therapy for Barrett's esophagus. Volume 136 of Issue 7. Gastroenterology 2009. PMID: 19272389


  113. Somsouk M, Gralnek IM, Inadomi JM. Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis. Volume 6 of Issue 6. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008. PMID: 18550005


  114. Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN. Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA. Volume 68 of Issue 1. Gastrointestinal endoscopy 2008. PMID: 18291393


  115. Somsouk M, Langfield DE, Inadomi JM, Yee HF. A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients. Volume 53 of Issue 4. Digestive diseases and sciences 2007. PMID: 17934829


  116. Inadomi JM, Somsouk MA. Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening? Volume 133 of Issue 4. Gastroenterology 2007. PMID: 17919513


  117. Inadomi JM, Somsouk MA. Proton pump inhibitors and hip fracture: cause for alarm? Volume 132 of Issue 5. Gastroenterology 2007. PMID: 17484900


  118. Steinmetz WE, Sparrow A, Somsouk M. Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints. Volume 43 of Issue 1. Magnetic resonance in chemistry : MRC 2005. PMID: 15468276


  119. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. Volume 10 of Issue 11. World journal of gastroenterology 2004. PMID: 15162527


  120. Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT. Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation. Volume 77 of Issue 5. Transplantation 2004. PMID: 15021833


  121. Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM. Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2. Volume 63 of Issue 20. Cancer research 2003. PMID: 14583460


  122. Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Volume 124 of Issue 7. Gastroenterology 2003. PMID: 12806627


  123. Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR. Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene. Volume 461 of Issue 1. Mutation research 2000. PMID: 10980409


  124. Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B. Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. Volume 273 of Issue 49. The Journal of biological chemistry 1998. PMID: 9830061